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This is why researchers are looking at new ways of supporting the liver, in particular the use of GLP-1 agonists
Anisimov et al
Thus, adequate folate intake is essential for preventing depression, due to its role in the synthesis of dopamine and serotonin, as well as dementia, through the prevention of neuronal damage ( 7 Vitamin B12 Vitamin B12, also known as cobalamin, plays a crucial role in the biochemistry of the nervous system, contributing to essential processes such as the synthesis of DNA, S-adenosylmethionine (SAM), and succinyl-CoA, all of which support nerve cell function and overall neurological health (70, 71)
The digestive symptoms experienced during GLP-1 therapy result from altered gastrointestinal motility and delayed gastric emptying rather than enzyme deficiency