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Based on the available data, SGLT-2 inhibitors represent an evidence-based therapeutic option for the management of overweight/obese patients with T2DM

However, mechanism does not automatically determine timing

The largest pharmaceutical market in the world is in North America, which has a strong market due to its high regional GDP, high per capita income, and increased healthcare awareness due to easy access to expensive medications

Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CMG, Duran M, Hof KHV, Eskes TKAB, Hautvast JGAJ, and Steegers-Theunissen RPM (1999)

These effects are typically dose-dependent and diminish with continued therapy