nejm semaglutide cardiovascular SELECT Trial SURPASS-2 (NEJM 2021) was the

Organic liquids such as acetone, ethanol, and tetrahydrofuran are sufficiently polar to be completely miscible with water yet sufficiently nonpolar to be completely miscible with all organic solvents

The effectiveness was gauged by noting the percentage of participants who achieved a minimum of 5% weight reduction

While that study did not focus on lactation transfer specifically, the overall lack of lactation-specific evidence is one reason many clinicians recommend postponing restart until breastfeeding or pumping ends

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The implication reframes the entire maintenance challenge