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If GLP-1-based RA therapies are diverted toward individuals seeking weight loss for non-medical reasons, it may exacerbate disparities in access and undermine the goal of supporting those with the greatest clinical need. Broadening access and prioritising the vulnerable These dynamics underscore the need for clear clinical guidelines and responsible prescribing practices across Southeast Asia
Abbreviations BP: Blood pressure CI: Confidence interval CIMT: Carotid intima-media thickness eGFR: Estimated glomerular filtration rate HbA1C: Hemoglobin A1c HDL: High-density lipoprotein cholesterol ICA: Internal carotid artery L-C: L-carnitine LDL-C: Low-density lipoprotein cholesterol Lp(a): Lipoprotein (a) MetS: Metabolic syndrome MI: Myocardial infarction MPH: Maximum plaque height NSAIDs: Nonsteroidal anti-inflammatory drugs SAEs: Serious adverse events TMAO: Metabolites such as trimethylamine oxidase TPA: Total plaque area TPV: Total plaque volume WC: Waist circumference References Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, et al
This practice is not supported by clinical research and is considered off label. Some people obtain (often by ordering online) compounded, or customized, versions of brand-name medications
