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GLP-1 inhibits glucagon secretion when plasma glucose concentration is high, while GIP acts at lower glucose levels

In an interview with Pharmacy Times , Donna Ryan, MD, professor emerita from the Pennington Biomedical Research Center in Baton Rouge, Louisiana, discusses the long-term treatment protocol associated with glucagon-like peptide-1 (GLP-1) receptor agonists and how research is underway to determine how patients can feasibly stop treatment

STEP UP and STEP UP T2D are ongoing trials that aim to evaluate the weight loss potential of semaglutide at a yet-to-be-approved dosage of 7.2mg/weekly, comparing it to the established 2.4mg/weekly dose for weight loss [19, 20]