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This complicated method of action shows its potential as a groundbreaking obesity and metabolic health medication, revealing its efficacy and wide range of therapeutic possibilities

Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

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10.1038/s41572-019-0092-1 57 FanJ.LiuH.WangJ.ZengJ.TanY.WangY.et al (2021)

Acta Diabetol 61 , 13091326 (2024)