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The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018

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603 Meanwhile, EGCG downregulates dual oxidase and NOX expression while increasing SOD and GPX4 activities to reduce lipid peroxidation, suggesting that EGCG plays a neuroprotective role mainly by restoring iron homeostasis and redox balance in PD Drosophila