A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonist use was associated with increased risk of biliary disease, with an overall relative risk of approximately 1.37
For most men in St
If you develop new gallbladder symptoms on GLP-1 therapy If biliary symptoms have started since beginning treatment, the diagnostic pathway is: Clinical history and examination Abdominal ultrasound the definitive imaging for gallstones Blood tests including liver function and inflammatory markers In selected cases, MRCP (a specialised MRI of the bile ducts) Once gallstones are confirmed, the question becomes whether to proceed with cholecystectomy
This remains speculative until detailed DXA body composition data from the Phase 3 trials becomes available
You'll start on a low dose so your body has time to adjust, and the dose increases gradually over the first 16 weeks. The standard schedule is 0.25mg once a week for the first four weeks, then 0.5mg, then 1mg, then 1.7mg, and finally 2.4mg as your ongoing maintenance dose from week 17 onwards. Each step lasts around four weeks. Your clinician may slow this down if you're struggling with side effects, or keep you on a lower dose if it's working well for you