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Researchers in JAMA Network Open reviewed the total cost of producing GLP-1 medications (as well as insulin and another classes of medicines used for diabetes) with an eye toward establishing a resource-based price so that these medications could be used to treat obesity and diabetes in low and middle income countries, where noncommunicable diseases such as heart disease and diabetes take a larger toll each year

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The reasons patients may prefer oral administration over the subcutaneous route are most often needle aversion and local skin reactions, the authors write