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An indirect evidence for an intrinsic cycle in Schwann cells has come from studies on bone marrow reorganisation revealing the nonmyelinating Schwann cells as regulators of the hematopoietic stem cell activity by keeping the hematopoietic stem cells in a hibernating state, from which they can switch to active proliferation, for example, after a haemorrhage (Yamazaki et al., 2011)

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Ital J Dermatol Venerol

doi: 10.3390/nu15030579 289 BonsackOCaronBBaumannCHebaACVieujeanSArnoneDet al

In ALS, alterations in SIRT1 levels have been determined in postmortem tissues from patients (Krner et al., 2013) and in mouse models of ALS (Han et al., 2012)