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Not protecting your skin from the sun will essentially reverse all the skin benefits of retinol use

If were strictly talking about patient compliance, non-invasive delivery is more favored

For starters, a 2021 meta-analysis of eleven clinical studies found that astaxanthin supplementation significantly improved skin moisture and elasticity compared to placebo, but doses above 6mg per day didnt provide additional wrinkle or hydration benefits beyond what 6mg provided.1 So if your primary goal is supporting skin health, a 6mg product like Doctors Best may be all you need

Kttgen et al., 2013)

(49) Note that methylation, which occurs during Phase II, will be impaired if you have the MTHFR gene variation