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In models of metabolic syndrome and coronary artery disease (CAD), chronic metformin therapy reduces cardiomyocyte apoptosis and improves myocardial function under ischemic stress (Stone et al., 2024)

Additionally, the peptide has been hypothesized to impact insulin-like growth factor 1 (IGF-1) production, which is theorized to play a pivotal role in anabolic processes

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doi: 10.1016/j.heares.2010.07.005