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Abstract Maintaining the balance of a cells redox function is key to determining cell fate

Figure 6 Having demonstrated that metformin treatment significantly inhibits oxidative phosphorylation in both in vitro and ex vivo models of rectal cancer, the effect of metformin on histologically-confirmed normal rectal tissue biopsies ( n =12, median age of 41.5 y) taken from non-cancer patients was assessed in real-time using the Seahorse XFe analyser

They might review the frequency of your treatments or explore other factors that could be contributing to this reaction

McMurray JJV, Solomon SD, Inzucchi SE, Kober L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Belohlavek J, Bohm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukat A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, OMeara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjostrand M, Langkilde AM

the Special Scientific Research Projects for Family Planning, Prenatal and Postnatal Care of PLA (21JSZ13)