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The exact cause is unclear, but the textbooks describe several recognised contributors: Focal increase in melanin within the basal layer (the deepest, foundation layer of the mouth lining) of the lining, with or without an increase in the number of melanocytes (the cells that make melanin)

If a patient finds themselves needing it more often than 2 doses per week, a re-evaluation of underlying issues or alternative therapies may be warranted

Potential tesamorelin side effects may include injection site reactions, swelling, joint discomfort, headaches, muscle aches, tingling sensations, and water retention

Due to this potential risk, use should be avoided in breast-feeding women

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