7.2 Nose-to-brain delivery of exendin-4 and insulin using penetratin Having established that intranasal insulin/L-penetratin administration was effective at mild stage of cognitive dysfunction but not at severe cognitive dysfunction in senescence-accelerated mice (Kamei et al., 2018), this group investigated the effectiveness of GLP-1 receptor agonist, exendin-4, in modulating severe cognitive impairment
After being permeabilized with 0.1% Triton X-100 for 5 minutes, they were then blocked in 1% BSA-supplemented PBS for 1 hour at room temperature, and then cultured with 1:200 lens culinaris (LCA)-FITC for 1 hour at room temperature
2-Deoxycytidine
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