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Growth hormone stimulates IGF-1 production by binding to GH receptors on liver cells and triggering intracellular signaling that upregulates IGF-1 gene expression

The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

Patients can evaluate tolerance, monitor for adverse effects, and establish baseline response before potential escalation