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[33] An editorial published in the Journal of the American Medical Association said that "the study findings may provide novel hypotheses that merit further evaluation to help understand the pathophysiology of secondary prevention of vascular disease." [40] Critics of the study characterized it as showing no support for the use of chelation therapy in coronary heart disease, particularly the claims that chelation reduces the need for coronary bypass surgeries

For athletes who require a prohibited substance or method but have a legitimate medical reason, they can apply for a Therapeutic Use Exemption (TUE) to meet the criteria outlined in the International Standard for Therapeutic Use Exemptions (ISTUE)

When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes

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Garcia, L., Rigoulet, M., Georgescauld, D., Dufy, B