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Notably, pyroptosis is a form of caspase-1 mediated proinflammatory programmed cell death that results from the activation of inflammasomes NLRPs and may lead to the imbalance of polarized macrophages during OA development [10], [11], [12]

M., Juan, C

Regular monitoring is essential, including baseline cardiovascular assessment, ongoing evaluation of symptom response, adverse effects, blood pressure, heart rate, and growth in children

Emerging observational data have raised questions about musculoskeletal safety, with special relevance for people already limited by pain

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