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Lee SY, Chang HJ, Sung J, Kim KJ, Shin S, Cho IJ, et al

It's important to communicate openly with your healthcare provider about any side effects you experience while taking GLP-1 agonists

Retatrutide is an investigational, single-molecule peptide agonist engineered to activate three related class B G-protein-coupled receptors: the glucose-dependent insulinotropic polypeptide receptor, glucagon-like peptide-1 receptor and glucagon receptor

Weeks 5-8 (first dose increase) After four weeks at the starting dose, most protocols call for the first dose increase

( Epub 2017 Dec 21 PMID: 29274348 ) Varpuluoma O, Jokelainen J, Huilaja L, Tasanen K (2021) GLP-1 analogs and SGLT2 inhibitors do not increase risk of bullous pemphigoid