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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

Split weekly dosing is evaluated as a tolerability strategy rather than a separate efficacy protocol

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For example, some doctors make multiple injections in small amounts between the tendons, while others may make one large injection in the center of the hand, and then direct the filler to where it needs to go once its under the skin