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C9orf72 protein can be recognized by T cells as an autoantigen, and this ALS-associated T cell autoreactivity was found broadly in ALS patients, though it was particularly high in C9orf72 mutation carriers (Michaelis et al., 2025)

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[PMC free article: PMC441465] [PubMed: 7533787] 308

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Enhanced therapeutic efficacy of combining Losartan and Chemo-Immunotherapy for Triple negative breast Cancer

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Whether that represents a systemic issue or an isolated incident is impossible to determine from public reviews alone

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