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TB-500 has a 2-day half-life and requires 4-6 weeks of consistent dosing at 2-5 mg per week to reach tissue saturation
This might have been due to the resolution of nerve root edema and inflammatory reactions in both groups by the end of the follow-up
However, so far, no significant adverse effects have been consistently reported
Week 2-4: Anti-inflammatory effects becoming more apparent
For sublingual or oral formulations, absorption may be better on an empty stomach, though specific research is limited
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