No significant differences were observed with metformin (WMD: 47.08
doi: 10.1097/SHK.0b013e3182184ee7 26 SchuijtTJLankelmaJMSciclunaBPde Sousa e MeloFRoelofsJJde BoerJDet al
In the diabetes TRIUMPH-2 trial, reported side effects included: Diarrhea (around 27 to 34 percent of participants, depending on the dose) Nausea (14 to 28 percent) Constipation (14 to 17 percent) Decreased appetite (6 to 17 percent) Vomiting (6 to 16 percent) In the TRIUMPH-3 trial for adults with severe obesity and heart disease, participants reported: Diarrhea (around 24 to 30 percent of participants, depending on the dose) Nausea (22 percent) Constipation (16 to 18 percent) Decreased appetite (14 to 15 percent) Hyperglycemia, or high blood sugar (3 to 4 percent) The high rates of diarrhea surprised Ali
It also plays a large role in protecting the brain and body from the effects of stress and inflammation which can result in diabetes, depression, anxiety, nausea and morning sickness, and more
It also comes with potential side effects, albeit rare ones, including breathing issues (with spray products) and skin inflammation in some people
