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It is a naturally occurring peptide that has been the subject of scientific interest for decades due to its connection to sleep-related research and neuropeptide signaling studies

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When hunger cues disappear on GLP-1s, scheduled eating every 3-4 hours, protein prioritization (60+ grams daily), and meal prepping become essential to prevent muscle loss, nutritional deficiencies, and common side effects like nausea and constipation

In addition, tirzepatide in particular has been found to compromise the absorption of oral contraceptives, which can contribute to accidental pregnancy

Prasad S, Kalra N, Singh M, Shukla Y