By the time we reach our 60s, levels have plummeted by as much as 60% compared to our 20s
10.1371/journal.pbio.2003853 PLoS Biol
A deeper understanding of these mechanisms and the identification of therapeutic targets are crucial for improving clinical outcomes in patients with chronic gout (179, 180)
Hence, it certainly appears that measurements in worms ex vivo of GSH/GSSG ratio and fluorescent product from TRFS-Green are more reliable in assessing endogenous inhibition of TGR
On other hand, prooxidant therapies, including ionizing radiation and chemotherapeutic agents, are widely used in clinics, based on the rationale that a further oxidative stimulus added to the constitutive oxidative stress in tumor cells should, in fact, cause the collapse of the antioxidant systems, leading to cell death [6]