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[2] [3] According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), gastrointestinal disturbances affect a substantial proportion of patients , particularly during the initial weeks of treatment or following dose escalation

SUSTAIN-6 was pivotal, revealing a 26% reduction in adverse heart outcomes

Postoperative efficacy was rated as excellent or good for 62 (95.4%) of the 65 procedures

They can improve epithelial barrier function, regulate immune responses, and are commonly used to prevent obesity and treat intestinal dysbiosis (Li et al., 2020

Retatrutide has not received marketing authorisation from the MHRA or EMA and is not approved for clinical use in the UK