Dual GIP/GLP-1 mechanism may produce different neurological effects than pure GLP-1 agonism
"Unfamiliarity with withdrawing medication from a vial into a syringe and coupled with confusion between different units of measurement (e.g., milliliters, milligrams and "units") may have contributed to dosing errors." The agency said patients should consult with a medical professional on how to measure and administer the correct dose, and that health care providers should "provide patients with the appropriate syringe size for the intended dose and counsel patients on how to measure the intended dose using the syringe." Semaglutide is the active ingredient in three FDA-approved medications, Wegovy, Ozempic and Rybelsus
Some you have likely heard of, like nausea, but others might be a little more surprising
When taken with insulin or sulfonylureas, low blood sugar can happen, so monitoring is required
Another systematic review from Berg and colleagues, also published in 2025, confirmed these findings across multiple GLP-1 receptor agonists PMID: 40186344
