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Some people experience discomfort from gallstones, together with other symptoms of the condition

This scenario hasnt been specifically studied

Tolerance development, inadequate dosing, or genetic variations in GLP-1 receptor sensitivity commonly cause plateaus within 36 months

doi: 10.1186/1472-6823-14-18

However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use