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Key preclinical findings included: Dose-dependent weight loss exceeding that of single- or dual-receptor agonists Improved glucose tolerance and insulin sensitivity Increased energy expenditure attributable to the glucagon receptor component Reduced hepatic steatosis Acceptable preclinical safety and toxicology profile These data supported an Investigational New Drug (IND) application to the FDA, enabling the transition to human clinical testing

Standard fridge-first peptides: Sermorelin, CJC-1295, Ipamorelin, TB-500, PT-141, GHRP-2, Gonadorelin Refrigerate unopened, freeze for long-term storage, and protect from light

Reconstituted GHK-Cu should be used within 21-30 days when refrigerated at 2-8C

FOLIC ACID requirements are far greater in athletic performance horses where the synthesis and absorption from the gut are reduced by the stress of training and performance

doi: 10.1007/s11695-022-06328 54 Le RouxCWBorgCWallisKVincentRPBueterMGoodladRet al