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In connection with this, antioxidants and weak prooxidants were evaluated in preclinical and clinical testing (Valko et al

More recently, red-emissive CQDs synthesised from Echinophora tenuifolia were shown to selectively stain non-viable cells with high fluorescent intensity and photostability, a property attributed to their negatively charged surface favouring interactions with compromised cellular membranes, sparing viable cells [98]

Despite some reports on the similarities between senescence and eryptosis at the morphological level [67], intracellular Ca 2+ elevation [74], Ca 2+ -driven activation of Gardos channels [70], PS exposure [76], or ROS contribution [71], senescence of erythrocytes cannot be considered an RCD of these cells and should be clearly distinguished from eryptosis

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Its been called the master antioxidant and for good reason