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H.BaxterM

TMP269, a potent and selective class IIa HDACs inhibitor, significantly improves the pathological changes including renal tubular dilation, cell debris accumulation in the renal tubular lumen, interstitial edema, and inflammatory cell infiltration in FA-/IRI-induced AKI mouse model by reducing the expression of HDAC4 to regulate pathways associated with apoptosis, autophagy, and proliferation

Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats

Grotto D, Valentti J, Boeira S, et al

In summary, we found that KG was required for histone acetylation via TMHLE-catalyzed carnitine synthesis to facilitate HR-mediated DNA repair in CCNE1-driven models