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At the brain vasculature, microglia exhibit a critical balance between protective and detrimental roles in neuroinflammation and BBB integrity

The structural similarity is real

The decrease in molecular oxygens valency due to electron loss leads to the formation of ROS (Watabe et al

Basic fibroblast growth factor (bFGF) protects the blood-brain barrier by binding of FGFR1 and Activating the ERK signaling pathway after intra-abdominal hypertension and traumatic brain injury

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