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A critical consideration is that rapid weight loss from any causewhether through medication, surgery, or lifestyle modificationis associated with bone density reduction, making it challenging to isolate the independent effect of GLP-1 medications from the effect of weight loss itself

Also, remember, if using a PPI long term, it is important to wean slowly off those medicines, as stopping abruptly can cause worsening reflux symptoms for the next several days, as the stomach acid may increase again quickly

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Interested parties' input was gathered at two Provider Leadership Workgroup meetings, two Person and Family Engagement Workgroup meetings and one Technical Expert Panel meeting between 2023 and 2024 in addition to the public comment period correlated with the Safety of Care Request for Information included in the CY 2025 OPPS Proposed Rule (89 FR 94514 through 94521)

GLP-1RAs contribute to metabolic adjustments in MASLD by controlling fat deposition, inflammation, and potentially fibrosis