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Metformin scored FDA approval in 1994 (1) to treat type 2 diabetes

If prior authorization is required, ask your prescriber to submit a clinical rationale and include supporting lab results to expedite approval

If the medicine becomes frozen at any point, throw it away, says Horn

Animal studies have suggested that metformin enhances the weight loss efficacy of GLP-1 RAs by stimulating GLP-1 receptor expression and augmenting insulin-mediated signaling pathways

Semaglutide, the active ingredient in Ozempic, is one of the most potent GLP-1 receptor agonists and may be a first-line option, especially in people with heart disease or obesity