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In an announcement published on 21 May 2026, Eli Lilly shared the results of the TRIUMPH-1 study, which involved 2,339 participants who were randomised to receive either retatrutide 4mg, 9mg, 12mg (building up every four weeks from 2mg), or placebo

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Current users are also notably less likely to report feelings of sadness and stress compared to the lookalike segment

The GLP-1 receptor is a Class B G-protein-coupled receptor expressed on pancreatic -cells, central nervous system neurons (notably in the hypothalamic arcuate nucleus and area postrema), gastric smooth muscle, and several cardiovascular tissues