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(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition

Once this production is continuous, ECM deposition becomes massive and, associated with the uncontrolled apoptosis of tubular cells, results in tubular atrophy 84

If constipation persists, consult your GP or diabetes team about appropriate laxatives such as macrogol

Older adults often experience changes in appetite and meal patterns, as earlier dinner times or reduced caloric intake at night