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Nutrients (2019) 11(10):2524

In MAD cohort 1 (100 mg/12 h), one participant was withdrawn from the study, following the advice of the Safety Review Committee, due to an event of proteinuria deemed mild and unrelated to study treatment, and most probably related to a pre-existing renal disease that was not detected during the screening period

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If you are losing weight consistently, tolerating the medication well, and progressing toward your goal, there is no clinical requirement to switch

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