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Meanwhile, mTORC1/S6K1 can also phosphorylate IRS-1 serine, thus block its activation 80 (Fig

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Additionally, by regulating glucose and lipid metabolism and suppressing the HIF-1/VEGF/NF-B pathway, it reduces the accumulation of retinal glycogen and levels of inflammatory factors, protecting the retina from damage induced by high glucose levels (Yin et al., 2021)