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The same gene defect can cause a severe and rapidly fatal childhood leukodystrophy or a more indolent adult-onset myelopathy and neuropathy

Methionine SAM (via MAT) methyl donor formation Homocysteine remethylation methionine (requires B12 ) Transsulfuration (CBS & CGL, needs B6 ) cysteine Cysteine + glutamate + glycine GSH (glutathione synthetase) Nutrient supports: B12, B6, folate for methylation & transsulfuration Sulfur-rich foods (garlic, onion, broccoli) Protein sources (eggs, fish, legumes) for amino acids Glutathione synthesis is the step-by-step process by which the body creates its master antioxidant to support detoxification, immunity, and cellular health

Reducing inflammation: Glutathione also helps the recovery process by reducing inflammation and speeding up tissue repair

By activating estrogen-related receptor proteins (ERRs), it may help support energy production, healthy fat metabolism, and balanced insulin function

However, both contain an active Q in position 2 of the peptide (Hitomi et al., 2009