The lean mass losses observed are broadly consistent with what you'd expect from equivalent caloric restriction, though the researchers noted that GLP-1 medicines have a distinct effect on the muscle proteome compared to calorie restriction alone
Excessive lactate production during exercise increases the acidity of blood and tissue fluid, reduces ATP generation, and leads to fatigue
This weight loss is typically gradual and is most effective when combined with a reduced-calorie diet and increased physical activity
Best JH, Hoogwerf BJ, Herman WH, Pelletier EM, Smith DB, Wenten M, et al
Had we just avoided ultra-high processed foods, (and all the other junk) we wouldnt be in this position