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Earlier studies demonstrated that the incretin effect of GIP was severely impaired in patients with uncontrolled T2DM ( In contrast, while the dose-response relationship between -cell responsiveness to glucose (expressed as the slope of the linear relation between insulin secretion rate and the glucose concentration) and GLP-1 levels in circulation is partially impaired a phenomenon referred as GLP-1 resistance ( Furthermore, a preclinical study conducted by Finan et al

Some of these risk factors directly contribute to disease (e.g., ApoB and cardiovascular disease), while others, like HDL cholesterol, primarily reflect broader metabolic health shaped by food, nutrition, and physical activity

doi: 10.1002/(sici)1097-0215(19970410)71:2 3.0.co;2-e

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