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Real-World Evidence: From Trials to Practice As obesity care moves from randomised clinical trials to everyday practice, real-world evidence is becoming more valuable for payers, providers, and policymakers

The small-molecule nature of 5-Amino-1MQ, compared to peptides, provides practical advantages: oral bioavailability, simpler administration, and potential for dose optimization through oral delivery

It also has three glycosylation sites necessary for insertion into the plasma membrane (17, 40)

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Figure 1 On this basis, this review summarizes the major regulatory mechanisms by which amino acid metabolism shapes macrophage polarization from the perspective of immunometabolic network integration, and further outlines the research progress in different autoimmune diseases