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The ETC consists of four oxidative phosphorylation (OXPHOS) complexes (IIV)

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The increase in ROS or RNS levels involves a concomitant increase of proinflammatory cytokines and the activation of NF-, which in turn activates the hepatic stellate cells, the subsequent fibrosis, and damage to the DNA [12,64], with a failure in the synthesis of exogenous antioxidants [12]

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These drugs are powerful and work by raising GLP-1 activity in the body to a level far above what happens naturally