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Cheng Y, Xu T, Li S, Ruan H

Several peptides have shown clinical interest in managing chronic pain and inflammation

Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

however, the precise mechanisms underlying this association are not yet fully understood

Vitamin B12 methylcobalamin converts homocysteine into methionine, which brings down homocysteine levels