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Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats

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Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)

Mol Pharmacol 58:328334 [DOI] [PubMed] [Google Scholar] Koch T, Schulz S, Pfeiffer M, Klutzny M, Schrder H, Kahl E, Hllt V

While not always mandatory, a blood test is recommended to assess your B12 levels and determine the best course of action for your treatment plan.