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Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

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We thank two anonymous reviewers for dedicating their time to review our manuscript

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Due to the well-known high glucose-mediated epigenetic changes, the potential role on DNA methylation of genes involved in neuroprotection and epigenetic modulators of neuronal growth (miRNA 34a), apoptosis (miRNA 212) and differentiation (miRNA 29c) was also investigated