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This quasi-operon organization facilitates coordinated expression in response to environmental triggers like nitrogen depletion or oxidative stress (63, 64)

doi: 10.1016/j.jsbmb.2011.08.007 11 SatarugSGarrettSHSensMASensDA

Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012

Such fine modulation of movement across the epithelium demands structural components that aid this process, such as transmembrane proteins including occludin, junctional adhesion molecules, and claudin protein family members that together maintain epithelial cell basolateral polarity (Shin et al