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It has been reported that in studies where high doses of milk thistle were taken for long periods of time, only 1% of people experienced any side effects, meaning that for the most part, milk thistle is relatively risk-free, as stated in the American Family Physician scientific journal: Aside from mild gastrointestinal distress and allergic reactions, side effects are rare, and serious toxicity rarely has been reported

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Some biotechnology products have visual appearance specifications for drug solutions that include comments such as essentially free of visible particulates or some translucent particles may be present (69)

Extracellular matrix components indicate remodelling activity in different fibrosis stages of human non-alcoholic fatty liver disease