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Pushing through excessive fatigue during aggressive fat loss protocols leads to overtraining syndrome, which actually increases muscle catabolism and slows fat loss

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doi: 10.1038/s41591-018-0297-y 55 OCarrollS

It should therefore not be described as having a confirmed polyproline helix or a proven SH3-domain-binding structure unless direct structural evidence becomes available

These objective markers are more reliable than subjective assessments, which are susceptible to expectation bias