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Tirzepatide: First Approval

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We confirmed these transcriptional changes in murine AKP organoid models treated with 5FU (Extended Data Fig

On the other hand, under the regulation of various cells and their secreted cytokines, key transcriptional regulation pathways such as TLR2/4-NF-B, p38/MAPK, IL-6/STAT3, and others participate in the immune-inflammatory interactions underlying diabetic vascular complications, ultimately leading to vascular damage and barrier disruption, triggering diabetes-related macrovascular and microvascular complications (Odegaard et al., 2016

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